Analytical Data
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Gene name
SCN2B
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简介
SCN2B protein is a key subunit of voltage-gated sodium channels and plays an important role in regulating channel function by interacting with the pore-forming α subunit. This interaction regulates the flux of sodium ions across the cell membrane, affecting neuronal excitability and action potential propagation. SCN2B Protein, Human (HEK293, His) is the recombinant human-derived SCN2B protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Sodium channel subunit beta-2; SCN2B
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
O60939
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Expression Region
M30-A159
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Protein Length
Partial
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Molecular Weight
21-34 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The SCN2B gene encodes the beta subunit of voltage-gated sodium channels, which play a crucial role in neuronal excitability and action potential propagation. Mutations in SCN2B have been implicated in various neurological disorders, including epilepsy, autism spectrum disorders, and other neurodevelopmental conditions. Understanding the functional role of SCN2B, both in its normal physiological context and in the pathological states caused by its mutations, has become a significant area of research. The development of recombinant SCN2B proteins allows scientists to investigate the structural and functional properties of these channels in detail. By studying the interaction of SCN2B with the alpha subunits and other associated proteins, researchers aim to elucidate the mechanisms by which SCN2B influences neuronal function and contributes to disease. Furthermore, recombinant SCN2B proteins can be utilized in high-throughput screening assays to identify potential therapeutic compounds that may restore normal channel function in disease states. This research not only advances our understanding of SCN2B's role in the nervous system but also opens potential avenues for targeted therapies in conditions associated with SCN2B dysregulation.
