Analytical Data
-
Gene name
GBP2
- Application
-
Alternative Names
(GTP-binding protein 2)(GBP-2)(HuGBP-2)(Guanine nucleotide-binding protein 2)(Interferon-induced guanylate-binding protein 2)
-
Species
Human
-
Source
E. coli
-
Tag
N- His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P32456
-
Expression Region
100-259aa
-
Molecular Weight
22.4 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GBP2, or Guanylate Binding Protein 2, is a crucial member of the GBP family, which plays a significant role in the immune response, particularly against intracellular pathogens such as viruses and certain bacteria. The study of GBP2 has gained traction in recent years due to its involvement in various immune regulatory processes, including the modulation of cytokine responses and the enhancement of autophagy. GBP2 can recognize and bind to specific guanosine triphosphates, leading to its activation and subsequent action in promoting host defense mechanisms. Notably, research has indicated that GBP2 is upregulated in response to interferon stimulation, highlighting its importance in the host's defense against infections. Given its potential therapeutic implications, understanding the structure-function relationship of GBP2 is vital for developing novel strategies to enhance immune responses or treat inflammatory diseases. Recent studies have focused on the molecular characterization and functional roles of GBP2, revealing its potential as a target for drug development in immunomodulatory therapies. As research continues, GBP2 is positioned as an important component of the innate immune response, warranting further investigation to explore its full potential in combatting infectious diseases and modulating immune pathways.
