Analytical Data
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基因名
FRZB
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简介
FRZB protein is a soluble Frizzled-related protein (sFRP) that modulates Wnt signaling by directly interacting with Wnt, thereby regulating cell growth and differentiation. FRZB, also known as SFRP3, plays a key role in limb skeletogenesis as a Wnt8 signaling antagonist. FRZB Protein, Human (HEK293, His) is the recombinant human-derived FRZB protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Secreted frizzled-related protein 3; sFRP-3; Frezzled; FrzB-1; FRZB; SFRP3
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92765
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表达区间
A32-N325
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氨基酸序列
AAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSKSDSSNSDSTQSQKSGRNSNPRQARN
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蛋白长度
Full Length of Mature Protein
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分子量
41 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FRZB, or Frizzled-related protein, is a secreted antagonist of the Wnt signaling pathway, which plays critical roles in cell proliferation, differentiation, and tissue homeostasis. Its discovery provided insights into the regulatory mechanisms governing embryonic development and cellular communication. Research has highlighted FRZB's importance in various biological processes, including bone density regulation and the development of certain cancers. Notably, alterations in FRZB expression have been associated with conditions such as osteoarthritis and multiple types of tumors. Given its involvement in key signaling pathways, FRZB has garnered attention as a potential therapeutic target. Investigations into the structure and function of FRZB have revealed its ability to bind to Wnt ligands, thereby inhibiting their interaction with Frizzled receptors. This has prompted studies aimed at understanding the molecular mechanisms of FRZB, its role in pathophysiological conditions, and the potential for utilizing FRZB-based interventions in regenerative medicine and cancer therapy. As research continues to uncover the multifaceted roles of FRZB, it holds promise for the development of novel strategies to modulate Wnt signaling in various diseases, making it a focal point of interest in contemporary biomedical research.
