Analytical Data
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基因名
Collagen alpha-1(II) chain/COL2A1
- Application
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别名
COL2-A1; COL2A1; SEDC; Chondrocalcin; Collagen Alpha-1(II)Chain; Primary Osteoarthritis,Spondyloepiphyseal Dysplasia,Congenital
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P02458
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表达区间
Gln26~Ala181
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分子量
29kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Collagen alpha-1(II) chain, encoded by the COL2A1 gene, is a key component of type II collagen, primarily found in cartilage, which provides structural support and resilience to cartilage tissues. Its importance in maintaining cartilage integrity makes it vital for normal joint function and overall skeletal development. Mutations in the COL2A1 gene are linked to various connective tissue disorders, including Achondrogenesis and Osteogenesis Imperfecta, which can lead to severe skeletal abnormalities. The recombinant protein of COL2A1 is increasingly being studied for its potential applications in regenerative medicine, particularly for cartilage repair and tissue engineering. The ability to produce recombinant COL2A1 allows for a detailed understanding of its molecular properties and interactions within the extracellular matrix. Furthermore, this research assists in developing biomimetic materials that can mimic the properties of native cartilage, promoting the repair and regeneration of damaged tissues. As the demand for effective treatments for cartilage-related diseases and injuries rises, the study of COL2A1 recombinant protein holds promise for advancing therapeutic strategies and improving patient outcomes in orthopedics and rheumatology.
