Analytical Data
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基因名
ADAM12
- Application
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别名
MCMP; MCMPMltna; MLTN; MLTNA; Meltrin Alpha; Disintegrin and metalloproteinase domain-containing protein 12
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种属
Human
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表达系统
HEK293
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
O43184
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表达区间
Arg29~Ser513
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分子量
68kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADAM12 (A Disintegrin and Metalloprotease 12) is a member of the ADAM family, which consists of membrane-anchored metalloproteases characterized by their disintegrin and metalloproteinase domains. Its expression is prominently observed during embryonic development and in various pathological conditions, particularly in cancer. Researchers are increasingly interested in ADAM12 due to its roles in cell adhesion, migration, and proliferation, which are critical processes in tumor progression and metastasis. The enzyme is also involved in the cleavage of various substrates, including growth factors and receptors, influencing signaling pathways that govern cellular behavior. Studies have shown that elevated levels of ADAM12 are associated with aggressive tumor phenotypes and poor patient prognosis in several cancer types, making it a potential biomarker for diagnosis and prognosis. The investigation into recombinant ADAM12 proteins aims to elucidate their structural and functional characteristics, thereby providing insights into their biochemical properties and potential therapeutic applications. Understanding ADAM12's mechanism of action could lead to the development of targeted therapies that inhibit its function, offering new avenues for treating cancer and other ADAM12-related diseases. Overall, the study of recombinant ADAM12 proteins is vital for uncovering the complexities of its roles in health and disease, paving the way for innovative strategies in regenerative medicine and oncology.
