Analytical Data
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Gene name
PAK5
- Application
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Alternative Names
/
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TB93
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Expression Region
425-719aa
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Molecular Weight
49.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The PAK5 gene, a member of the p21-activated protein kinase family, plays a critical role in various cellular processes, including cytoskeletal dynamics, neuronal development, and signal transduction pathways. Its implications in cancer progression, particularly in aggressive tumors, have spurred interest in studying PAK5 as a potential therapeutic target. Research has revealed that PAK5 is involved in regulating cell motility, survival, and proliferation, making it a key player in metastasis and tumor growth. Moreover, its unique structural features allow for specific interactions with cellular partners, which can further modulate signaling pathways crucial for cancer cell behavior. Understanding the biochemical properties and regulatory mechanisms of PAK5 through recombinant protein studies not only aids in unraveling its function in normal physiology but also provides insights into its aberrant activities in pathological conditions. The production of recombinant PAK5 protein facilitates various functional assays, including substrate specificity tests and inhibitor screening, contributing to the development of targeted therapies. Overall, elucidating the structure and functionality of PAK5 is essential for advancing our knowledge of its roles in human diseases and for potentially identifying novel intervention strategies.
