Analytical Data
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基因名
Niemann Pick C2/NPC2
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简介
Niemann-Pick C2/NPC2 protein is an important member of the NPC2 family and plays an important role in lipid metabolism and transport, helping to regulate intracellular cholesterol homeostasis and lipid transport.Its involvement in cellular processes highlights its importance in maintaining lipid homeostasis.Niemann Pick C2/NPC2 Protein, Rat (HEK293, His) is the recombinant rat-derived Niemann Pick C2/NPC2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
NPC intracellular cholesterol transporter 2; Niemann-Pick disease type C2 protein; HE1
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种属
Rat
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q8CHN5
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表达区间
E20-G149
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蛋白长度
Full Length of Mature Protein
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分子量
19-22 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Niemann-Pick type C2 (NPC2) is a crucial protein involved in intracellular lipid transport, specifically the transport of cholesterol and other lipids within cells. Mutations in the NPC2 gene lead to Niemann-Pick disease, a rare, neurodegenerative disorder characterized by the accumulation of unesterified cholesterol and other lipids in lysosomes. This accumulation results in progressive neurodegeneration, organomegaly, and other debilitating symptoms. Research into NPC2 and its recombinant protein forms is vital for understanding the molecular mechanisms underlying the disease and for developing potential therapeutic strategies. Recombinant NPC2 protein studies provide insights into its structure, function, and interaction with lipid membranes, which are critical for elucidating how lipid transport is disrupted in Niemann-Pick disease. Furthermore, the availability of recombinant NPC2 allows for the exploration of gene therapy approaches aimed at restoring proper lipid metabolism in affected patients. Overall, NPC2 research not only enhances our understanding of a complex metabolic disorder but also holds promise for innovative treatments that could significantly improve the quality of life for individuals affected by Niemann-Pick disease.
