Analytical Data
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Gene name
Apolipoprotein E
- Application
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Alternative Names
Apolipoprotein E; Apo-E; APOE; apolipo E; APOE4
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P02649
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Expression Region
19-317aa
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Molecular Weight
36-38 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
Apolipoprotein E (APOE) is a crucial protein involved in lipid metabolism, playing a significant role in the transport and clearance of lipoproteins from the bloodstream. Among its alleles, APOE4 has been identified as a major genetic risk factor for Alzheimer's disease (AD) due to its association with increased amyloid plaque deposition and neuroinflammation. Research has shown that individuals carrying the APOE4 allele have a higher risk of developing AD, with an earlier onset compared to non-carriers. The study of recombinant APOE4 protein is vital for understanding its structure, function, and the underlying mechanisms contributing to neurodegenerative disorders. By focusing on recombinant forms of APOE4, researchers aim to elucidate its pathological effects, explore potential therapeutic strategies, and develop targeted interventions that could mitigate the risk associated with this allele. Additionally, insights gained from studying APOE4 in vitro and in vivo could advance our comprehension of lipid-related processes in the brain and their implications in AD pathology. Overall, the exploration of APOE4 recombination represents a promising frontier in molecular research, bridging genetic, biochemical, and clinical perspectives in the effort to combat Alzheimer's disease.
