Analytical Data
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基因名
GUCY1A2
- Application
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别名
GCS-alpha-2
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P33402
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表达区间
500-732aa
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分子量
27.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GUCY1A2, part of the guanylate cyclase family, encodes the alpha-1 subunit of soluble guanylate cyclase, an essential enzyme involved in the nitric oxide (NO) signaling pathway. This pathway plays a crucial role in various physiological processes, including vasodilation, neurotransmission, and cellular signaling. Mutations in GUCY1A2 have been correlated with various cardiovascular and neurological disorders, highlighting its significance in human health and disease. Recent studies have focused on the recombinant expression of GUCY1A2 to better understand its function and regulatory mechanisms, as well as to develop potential therapeutic strategies for conditions associated with its dysregulation. Recombinant GUCY1A2 protein provides a versatile tool for biochemical assays and structural studies, facilitating the exploration of its interaction with NO and other signaling molecules, and contributing to drug discovery efforts aimed at modulating guanylate cyclase activity. Enhanced understanding of GUCY1A2's role in cellular processes could lead to innovative therapeutic approaches for managing diseases linked to nitric oxide signaling, thus underscoring the importance of continued research in this area.
