Analytical Data
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Gene name
Mamu-A*08 B2M Monomer
- Application
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Alternative Names
Mamu-A*08 & B2M
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Species
Rhesus Macaque
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Source
HEK293
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Tag
C-Avi;C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9MW40 (G17-P299)&Q6V7J5
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Expression Region
Q9MW40 (G17-P299)&Q6V7J5 (I21-M119)
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Molecular Weight
40-42 kDa and 10 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Mamu-A*08 B2M monomer is a recombinant protein that plays a crucial role in the study of immune responses in non-human primates, particularly in macaques, which are often used as models for human diseases. The Mamu-A*08 allele is associated with protective responses against viral infections, such as simian immunodeficiency virus (SIV), making it an important focus for vaccine development and immunological research. Understanding the structure and function of the Mamu-A*08 B2M monomer, a component of the major histocompatibility complex (MHC) class I molecules, is essential for elucidating how these molecules present antigens to T cells and influence immune recognition. The recombinant expression of this protein enables detailed studies of its interactions with peptide antigens and T cell receptors, providing insights into the mechanisms of immune evasion by pathogens and informing the design of novel immunotherapeutic strategies. Furthermore, researching Mamu-A*08 B2M monomer contributes to broader efforts to translate findings from non-human primate models to human applications, particularly in personalized medicine and vaccine design aimed at enhancing immune responses against infectious diseases and cancers.
