Analytical Data
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基因名
DCLK2
- Application
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别名
DCAMKL2; 2DCDC3; DCDC3B; DCK2; doublecortin and CaM kinase-like; CaMK-like CREB regulatory kinase 2; Doublecortin domain-containing protein 3B
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N568
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表达区间
Met1~Cys246
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分子量
61kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DCLK2 (Doublecortin-like kinase 2) is a non-canonical member of the doublecortin family of proteins, which are primarily known for their roles in neurodevelopment and neuronal function. Recent studies have highlighted DCLK2's potential involvement in various pathophysiological processes, including neurogenesis, synaptic plasticity, and potentially in cancer biology. As a kinase, DCLK2 is believed to function in signaling pathways that regulate cell division and differentiation, making it a target of interest for both neurobiological and oncological research. Its expression is notably elevated in certain cancers, particularly neuroendocrine tumors, where it appears to correlate with tumor aggressiveness and poor prognosis. Understanding DCLK2's structure and function through recombinant protein studies can shed light on its mechanisms in cellular signaling and its role in disease progression. Additionally, the development of DCLK2 inhibitors or modulators could offer novel therapeutic approaches in treating conditions associated with its dysregulation, such as cancer and neurodegenerative diseases. This highlights the importance of studying DCLK2 recombinantly to elucidate its biological roles and therapeutic potential.
