Analytical Data
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Gene name
PRKCI
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简介
PKC iota proteins are members of the calcium-dependent cell adhesion protein family and play critical roles in cellular interactions. PKC iota acts through a calcium-dependent mechanism and exhibits a preference for homogeneous interacting, connecting cells. PRKCI Protein, Human (sf9, GST) is the recombinant human-derived PRKCI, expressed by Sf9 insect cells, with GST labeled tag.
- Application
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Alternative Names
PRKCI; protein kinase C, iota; DXS1179E; protein kinase C iota type; PKCI; PRKC-lambda/iota; aPKC-lambda/iota; atypical protein kinase C-lambda/iota; nPKC-iota; MGC26534
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Species
Human
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Source
Baculovirus
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Tag
GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41743
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Expression Region
P2-V596
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Protein Length
Full Length of Mature Protein
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRKCI, or Protein Kinase C iota, is a crucial member of the protein kinase C family, which plays significant roles in various cellular processes, including cell growth, differentiation, and apoptosis. Its dysregulation has been implicated in several diseases, particularly cancer, where it often contributes to tumor progression and resistance to therapies. Research into PRKCI has gained momentum due to its potential as a therapeutic target; however, understanding its structure and function remains challenging due to the complexity of kinase signaling pathways. PRKCI is known to interact with multiple scaffolding proteins and participate in various cellular signaling cascades, highlighting its importance in maintaining cellular homeostasis. Recent advancements in biotechnology have enabled the production of recombinant PRKCI proteins, facilitating detailed biochemical studies and providing insights into its mechanism of action. Investigating the structural and functional characteristics of PRKCI at the molecular level can elucidate its role in disease progression and identify potential strategies for modulation. This research is pivotal not only for developing targeted therapies but also for enhancing our overall understanding of kinase biology in health and disease.
