Analytical Data
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Gene name
MKNK2
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简介
MKNK2 is a serine/threonine protein kinase that centrally affects cellular processes by phosphorylating SFPQ/PSF, HNRNPA1, and EIF4E. MKNK2 sits at the intersection of environmental stress and cytokine signaling and regulates translation by enhancing the affinity of EIF4E for the mRNA cap, thereby affecting the translation machinery. MKNK2 Protein, Human is the recombinant human-derived MKNK2 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HBH9
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Expression Region
T72-R385
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MKNK2, also known as MAP kinase-interacting serine/threonine-protein kinase 2, plays a critical role in various cellular processes, including mitochondrial function, apoptosis, and the regulation of translation. Its involvement in the MAPK signaling pathway underscores its significance in translating extracellular signals into appropriate cellular responses. Dysregulation of MKNK2 has been implicated in various pathological conditions, notably cancer and neurodegenerative diseases, highlighting the potential therapeutic value of studying this protein. Recent research has focused on the recombinant expression and purification of MKNK2 to investigate its functional properties and interactions with other cellular components. By utilizing advanced techniques such as protein crystallography and mass spectrometry, scientists aim to elucidate the structure-function relationship of MKNK2 and its regulatory mechanisms. Understanding the molecular underpinnings of MKNK2 not only contributes to fundamental biological knowledge but also opens avenues for developing targeted therapeutic strategies, especially in diseases where MKNK2 activity is aberrant. This research area is particularly promising as it bridges the gap between basic science and clinical application, aiming to enhance our understanding of MKNK2's role in health and disease.
