Analytical Data
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基因名
MAPKAPK2
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简介
The MAPKAPK2 protein is a stress-activated kinase involved in multiple cellular processes, including cytokine production, endocytosis, cytoskeletal reorganization, cell migration, cell cycle control, chromatin remodeling, DNA damage response, and transcriptional regulation. MAPKAPK2 Protein, Human (His) is the recombinant human-derived MAPKAPK2 protein, expressed by E. coli , with N-6*His labeled tag and ΔH217-P237, S216G mutation.
- Application
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别名
MAPKAPK2; MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49137
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表达区间
H47-R364, ΔH217-P237, S216G
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAPKAPK2 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2) is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and stress responses. It is activated by the MAPK pathway, which is known to be involved in the cellular response to extracellular signals, such as growth factors and cytokines. The research on MAPKAPK2 has gained importance due to its implications in various diseases, including cancer and inflammatory disorders. Understanding its structural characteristics and biochemical properties through recombinant protein expression is essential for elucidating its mechanism of action. Recombinant MAPKAPK2 enables the study of its enzymatic activity, substrate specificity, and interactions with other cellular proteins. This research can also facilitate the development of target-specific inhibitors, contributing to new therapeutic strategies. Additionally, investigating MAPKAPK2's role in signaling networks enhances our understanding of cellular communication and the regulation of physiological processes. Overall, the study of recombinant MAPKAPK2 represents a significant area of research with potential implications in both basic biology and translational medicine.
