Analytical Data
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基因名
ALK-7
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简介
ALK-7 is a type I receptor serine-threonine kinase mediate inhibitory as well as stimulatory signals for growth and differentiation by binding to members of the TGF-β superfamily. ALK-7 combined with specific ligands, such as Nodal, activin B and growth differentiation factor (GDF), can activate Smads and other signaling pathways, thereby regulating cell proliferation, differentiation and apoptosis in various cells[1][2][3]. ALK-7 Protein, Rhesus Macaque (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 89 amino acids (G25-E113).
- Application
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别名
Activin receptor type IC; ACTR-IC; ACVRLK7; ALK7
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种属
Rhesus Macaque
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
F7GDQ6
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表达区间
G25-E113
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蛋白长度
Partial
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分子量
43-70 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ALK-7, or Activin receptor-like kinase 7, is a member of the transforming growth factor-beta (TGF-β) superfamily, which plays a significant role in various biological processes, including embryonic development, immune responses, and tissue homeostasis. Recent research has focused on its involvement in neurobiology, particularly in relation to pain modulation and neuroinflammation. Studies have shown that ALK-7 is expressed in the central nervous system and is implicated in the development of pain hypersensitivity and other neurological disorders. Its signaling pathway can influence the production of inflammatory cytokines and neuropeptides, making it a potential target for therapeutic interventions in conditions like chronic pain and neurodegeneration. Furthermore, given its unique expression patterns and functional properties, researchers are exploring the prospects of ALK-7 as a biomarker for certain diseases, as well as its potential in regenerative medicine. The growing interest in ALK-7 research reflects an increasing recognition of the importance of TGF-β superfamily members in complex physiological and pathological processes, paving the way for novel strategies in treating pain and other related disorders.
