Analytical Data
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Gene name
Mer
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简介
Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1 or GAS6.Mer is critical in processes such as cell survival, migration, differentiation, and phagocytosis of apoptotic cells, and autophosphorylation occurs upon ligand binding.Mer Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Mer protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Tyrosine-protein kinase Mer; MERTK; MER
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Species
Mouse
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q60805
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Expression Region
M1-F498
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Protein Length
Partial
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Molecular Weight
130 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Mer receptor tyrosine kinase (MerTK) is a member of the TAM receptor family, which includes Tyro3 and Axl, and plays a crucial role in regulating innate immunity, cellular survival, and resolution of inflammation. It is primarily expressed in macrophages, dendritic cells, and retinal pigment epithelium, where it facilitates the removal of apoptotic cells, thus maintaining tissue homeostasis and preventing autoimmunity. Dysregulation of MerTK is associated with various diseases, including cancer, where it can promote tumor growth and evade immune surveillance. Additionally, MerTK has garnered attention for its involvement in neurodegenerative diseases, such as Alzheimer’s, where its expression can influence neuroinflammation. The study of MerTK and its signaling pathways aims to elucidate its multifaceted roles in health and disease. Researchers are exploring the potential of MerTK as a therapeutic target, leveraging its ability to modulate immune responses and enhance the clearance of harmful cellular debris. Understanding the molecular mechanisms underlying MerTK functions may reveal novel strategies for treating conditions like cancer, autoimmune disorders, and neurodegeneration, highlighting its significance in both basic and translational research.
