Analytical Data
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Gene name
P38β
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简介
The P38β protein is an important serine/threonine kinase in the MAP kinase pathway that responds to extracellular stimuli, including proinflammatory cytokines and physical stress. As part of the p38 MAPK family, P38β directly activates transcription factors that phosphorylate many proteins, including RPS6KA5/MSK1 and RPS6KA4/MSK2. P38β Protein, Human (sf9) is the recombinant human-derived P38β protein, expressed by sf9 insect cells , with tag free.
- Application
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Alternative Names
MAPK11; Mitogen-activated protein kinase 11; MAP kinase 11; MAPK 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15759
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Expression Region
S2-Q364
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
P38β, a member of the p38 mitogen-activated protein kinase (MAPK) family, plays a crucial role in various cellular processes, including inflammation, stress response, and cell differentiation. The interest in P38β has heightened due to its involvement in various pathological conditions, such as cancer, cardiovascular diseases, and neurodegenerative disorders. Unlike its counterparts, P38α, P38γ, and P38δ, P38β exhibits unique regulatory mechanisms and tissue-specific expression patterns, making it a potential target for therapeutic interventions. Researchers have focused on the structural and functional characterization of recombinant P38β protein to better understand its activation, substrate specificity, and downstream signaling pathways. The production of recombinant P38β allows for in-depth studies of its biochemical properties and interactions with other cellular proteins. Furthermore, understanding the role of P38β in disease models could lead to the development of selective inhibitors that modulate its activity, offering new avenues for treating diseases where P38β is implicated. Overall, the investigation of P38β recombinant protein serves as a foundational element in elucidating its biological functions and therapeutic potentials.
