Analytical Data
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Gene name
BMX
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简介
BMX proteins are nonreceptor tyrosine kinases that centrally regulate various signaling pathways that control actin dynamics, migration, proliferation, and survival. BMX participates in signal transduction of multiple receptors such as integrins, growth factor receptors, and cytokine receptors, induces BCAR1 tyrosine phosphorylation, and plays a key role in TNF-induced angiogenesis. BMX Protein, Human (sf9, His) is the recombinant human-derived BMX protein, expressed by sf9 insect cells , with N-8*His labeled tag.
- Application
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Alternative Names
BMX; Cytoplasmic tyrosine-protein kinase BMX; Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38
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Species
Human
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Source
Baculovirus
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Tag
N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51813
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Expression Region
E411-H675
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BMX (Bone Marrow Xkinase) is a non-receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and survival. Originally identified for its involvement in hematopoietic cells, research has expanded to explore its implications in cancer biology, autoimmune diseases, and cardiovascular disorders. The interest in BMX has surged due to its association with signaling pathways that govern cellular responses to external stimuli. Notably, BMX is implicated in the regulation of oncogenic pathways, making it a potential therapeutic target in cancer treatment. The study of BMX's structure, function, and its role in cellular signaling networks is vital for understanding its biological functions and for developing novel interventions. Recent advancements in molecular biology techniques have allowed researchers to investigate BMX's interactions with other proteins and its downstream effects, providing insights into its regulatory mechanisms. Furthermore, the exploration of BMX as a biomarker for disease progression highlights its relevance in clinical diagnostics and therapeutic strategies. As research continues to unravel the complexities of BMX signaling, it paves the way for innovative approaches in drug development and personalized medicine.
