Analytical Data
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Gene name
MUSK
- Application
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Alternative Names
Muscle-specific tyrosine-protein kinase receptor
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15146
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Expression Region
24-495aa
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Molecular Weight
56.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MUSK (Muscle-Specific Kinase) is a critical receptor tyrosine kinase predominantly expressed in skeletal muscle and plays a pivotal role in neuromuscular synapse formation and maintenance. The study of MUSK protein has gained attention due to its essential functions in muscle development and its implications in various neuromuscular disorders. Researchers have identified that MUSK interacts with other proteins such as agrin and dystroglycan, facilitating the clustering of acetylcholine receptors (AChRs) at the neuromuscular junction, which is vital for effective muscle contraction and movement. Dysregulation of MUSK signaling pathways can lead to severe conditions, including myasthenia gravis and congenital myasthenic syndrome. Moreover, investigations into MUSK's structural and functional properties can enhance our understanding of its role in muscle physiology and pathology. Advanced techniques such as X-ray crystallography and cryo-electron microscopy have been employed to elucidate MUSK's molecular mechanism, providing insights for potential therapeutic strategies targeting neuromuscular diseases. Because of its significance in muscle biology and the potential to influence therapeutic designs, the research on MUSK protein continues to evolve, aiming to develop innovative treatments that can improve the quality of life for individuals affected by neuromuscular disorders.
