Analytical Data
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基因名
TrkB
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简介
TrkB Protein is a neurotrophic factor receptor and a member of the tropomyosin receptor kinase family. TrkB Protein has high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation. TrkB Protein has carcinogenic activity. TrkB Protein, Canine (HEK293, Fc) is the recombinant canine-derived TrkB protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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别名
BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TRKB
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种属
Canine
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A0A8C0LGP8
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表达区间
C32-H430
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TrkB (Tropomyosin receptor kinase B) is a receptor for brain-derived neurotrophic factor (BDNF), which plays a critical role in neuronal survival, differentiation, and synaptic plasticity. Research on TrkB recombinant protein has gained traction due to its implications in neurological disorders, such as depression, Alzheimer's disease, and schizophrenia. The study of TrkB and its signaling pathways is essential for understanding the mechanisms underlying neurodevelopment and neurodegeneration. Recombinant TrkB proteins are utilized in a variety of experimental settings to explore their binding interactions with BDNF and other neurotrophic factors, enabling researchers to dissect the signaling cascades activated upon receptor activation. Additionally, these studies are instrumental in the development of potential therapeutic interventions aimed at modulating TrkB signaling for neuroprotection and cognitive enhancement. Given the increasing prevalence of mental health disorders and neurodegenerative diseases, the investigation of TrkB recombinant proteins represents a significant endeavor in the pursuit of innovative treatment strategies that can promote neuronal health and functional recovery.
