Analytical Data
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基因名
ACAA1
- Application
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别名
Acetyl-CoA acyltrans ferase;Beta-ketothiolase;Peroxisomal 3-oxoacyl-CoA thiolase
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P09110
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表达区间
27-331aa
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分子量
47.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACAA1, or Acetyl-CoA acyltransferase 1, is a key enzyme involved in the metabolic pathway of fatty acid oxidation, specifically in the peroxisomes and mitochondria. This enzyme catalyzes the conversion of acyl-CoA to 3-ketoacyl-CoA, an important step in the degradation of fatty acids. Mutations in the ACAA1 gene have been associated with various metabolic disorders, including peroxisomal biogenesis disorders and specific forms of acyl-CoA oxidation defects. The study of ACAA1-recombinant proteins has gained increased attention due to its potential implications in understanding these metabolic conditions and developing targeted therapies. By generating and characterizing recombinant ACAA1 proteins, researchers aim to elucidate the enzyme's structure, function, and regulatory mechanisms. Understanding these aspects is crucial for elucidating the pathological mechanisms underlying ACAA1-related disorders and exploring potential therapeutic strategies that could improve patient outcomes. Furthermore, recombinant ACAA1 proteins can serve as valuable tools in metabolic engineering and synthetic biology, enabling the development of bioindustrial applications that leverage fatty acid metabolism. Through comprehensive research on ACAA1, scientists hope to pave the way for innovative treatments for metabolic diseases and advance our understanding of lipid metabolism in human health.
