Analytical Data
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基因名
HK3/Hexokinase-3
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简介
The HK3 (hexokinase-3) protein promotes the phosphorylation of hexoses (i.e., D-glucose and D-fructose) to form hexose-6-phosphate (specifically, D-glucose 6-phosphate and 6-phosphate), Plays a vital role in cell metabolism. D-fructose 6-phosphate. HK3/Hexokinase-3 Protein, Human (sf9, His-GST) is the recombinant human-derived HK3/Hexokinase-3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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别名
Hexokinase-3; HK III; Hexokinase-C; HK3
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种属
Human
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表达系统
Baculovirus
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标签
N-His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P52790
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表达区间
M1-V923
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蛋白长度
Full Length
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分子量
115 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HK3, or Hexokinase-3, is an enzyme that plays a crucial role in glucose metabolism by phosphorylating glucose to form glucose-6-phosphate, a key step in both glycolysis and cellular energy production. The study of HK3 is particularly significant due to its implications in various physiological and pathological processes, including cancer metabolism, diabetes, and neurodegenerative diseases. Unlike other isoforms of hexokinase, HK3 is less understood but appears to exhibit unique regulatory mechanisms and tissue distribution, prompting interest in its potential as a therapeutic target. Research into the recombinant expression of HK3 aims to provide insight into its structure-function relationship, regulatory pathways, and interaction with other metabolic enzymes. By producing HK3 as a recombinant protein, scientists can conduct detailed biochemical studies, structural analyses, and drug screening assays to develop targeted therapies. Understanding HK3's role in metabolic pathways could lead to novel approaches for managing metabolic disorders and enhancing cellular energy efficiency. The ongoing exploration of HK3 not only enriches our knowledge of cellular metabolism but also opens avenues for innovative treatments in metabolic diseases.
