Analytical Data
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基因名
BRPF3
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简介
The BRPF3 protein is a scaffold in various HAT complexes such as MOZ/MORF and HBO1 and is critical for histone H3 acetylation, especially in directing the specificity of KAT7/HBO1 for H3K14ac. In the HBO1 complex, BRPF3 promotes DNA replication initiation and activates replication origins. BRPF3 Protein, Human is the recombinant human-derived BRPF3 protein, expressed by E. coli , with tag free.
- Application
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别名
BRPF3; Bromodomain and PHD finger-containing protein 3
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9ULD4
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表达区间
D1056-G1195
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BRPF3 (Bromodomain and PHD finger-containing protein 3) is a member of the BRPF family, which is part of the larger family of proteins that contain bromodomains and PHD (Plant Homeodomain) fingers, integral to chromatin remodeling and transcriptional regulation. Research on BRPF3 has gained traction due to its important role in the regulation of gene expression and its involvement in critical biological processes such as cell proliferation and differentiation. Mutations or dysregulation of BRPF3 have been linked to various types of cancers and other diseases, highlighting its potential as a therapeutic target. Furthermore, BRPF3 interacts with several key proteins, including histone acetyltransferases and other epigenetic regulators, making it a crucial player in the histone modification landscape. Understanding the structure and function of BRPF3, particularly through the study of its recombinant protein, is essential for elucidating its mechanism of action and exploring its role in cellular signaling pathways. As such, BRPF3 represents a significant focus of research in the fields of molecular biology, epigenetics, and cancer biology, aiming to develop innovative strategies for disease intervention and treatment.
