Analytical Data
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基因名
GEMIN6
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简介
The GEMIN6 protein is a component of the SMN complex and is critical for the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential for spliceosome-mediated pre-mRNA splicing. Most spliceosomal snRNPs share a common set of Sm proteins that form a heptameric protein ring on small nuclear RNAs. GEMIN6 Protein, Human (His, Strep) is the recombinant human-derived GEMIN6 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.
- Application
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别名
GEMIN6; Gem-associated protein 6; Gemin-6; SIP2
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种属
Human
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表达系统
E. coli
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标签
N-StrepⅡ;N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WXD5
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表达区间
M1-Q167
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GEMIN6, a key component of the survival of motor neuron (SMN) complex, plays a critical role in the biogenesis and maintenance of small nuclear ribonucleoproteins (snRNPs), which are essential for mRNA splicing. Research into GEMIN6 has garnered interest due to its involvement in spinal muscular atrophy (SMA), a genetic disorder characterized by the degeneration of motor neurons. The SMN complex, which includes GEMIN6, is vital for RNA metabolism and cellular functions, with its dysfunction leading to the pathology observed in SMA patients. Additionally, GEMIN6 has been implicated in various cellular processes beyond snRNP assembly, including the regulation of gene expression and cellular stress responses. Understanding the precise mechanisms by which GEMIN6 operates and its interactions with other SMN complex components can provide insights into potential therapeutic strategies for SMA and other related neurodegenerative diseases. The recombinant expression and characterization of GEMIN6 are crucial for elucidating its structure-function relationships, allowing researchers to explore its role in health and disease and the potential for targeted interventions.
