Analytical Data
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Gene name
CASK
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简介
CASK protein is a Mg(2+)-independent multidomain scaffold kinase that catalyzes phosphate transfer to proteins, including NRXN1, thereby contributing to synaptic transmembrane protein anchoring and ion channel trafficking. It plays a critical role in neural development, regulation of gene expression through TBR1 interactions, and mediates connections between the extracellular matrix, multiligands, and the actin cytoskeleton. CASK Protein, Human (sf9) is the recombinant human-derived CASK protein, expressed by Sf9 insect cells , with tag free.
- Application
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Alternative Names
Peripheral plasma membrane protein CASK; hCASK; CASK; LIN2
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14936-4
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Expression Region
A2-Y898
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Protein Length
Full Length of Isoform-4
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Molecular Weight
102 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CASK (Calcium/Calmodulin-dependent Serine Kinase) is a critical protein implicated in various cellular processes, including synaptic signaling, cell adhesion, and cytoskeletal organization. As a multi-domain protein, CASK interacts with numerous binding partners, influencing neuronal function and development. Dysregulation of CASK has been linked to several neurological disorders and developmental conditions, highlighting its importance in maintaining cellular homeostasis. In recent years, research has focused on understanding the structural and functional dynamics of CASK, particularly in relation to its role in synaptic plasticity and neurotransmitter release. The study of CASK has advanced with the advent of recombinant protein technologies, allowing for the production of high-purity CASK proteins for biochemical and structural studies. These investigations aim to elucidate the precise molecular mechanisms by which CASK exerts its functions, providing insights into potential therapeutic targets for conditions associated with CASK dysfunction. Additionally, the development of CASK-based biosensors and other biotechnological applications underscores its versatility and significance in both fundamental research and clinical settings. As the complexity of CASK interactions with other cellular components is unveiled, it offers a promising avenue for advancing our understanding of cellular signaling pathways and their implications in health and disease.
