Analytical Data
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基因名
CASK
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简介
CASK protein is a Mg(2+)-independent multidomain scaffold kinase that catalyzes phosphate transfer to proteins, including NRXN1, thereby contributing to synaptic transmembrane protein anchoring and ion channel trafficking. It plays a critical role in neural development, regulation of gene expression through TBR1 interactions, and mediates connections between the extracellular matrix, multiligands, and the actin cytoskeleton. CASK Protein, Human (sf9) is the recombinant human-derived CASK protein, expressed by Sf9 insect cells , with tag free.
- Application
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别名
Peripheral plasma membrane protein CASK; hCASK; CASK; LIN2
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种属
Human
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表达系统
Baculovirus
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14936-4
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表达区间
A2-Y898
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蛋白长度
Full Length of Isoform-4
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分子量
102 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CASK (Calcium/Calmodulin-dependent Serine Kinase) is a critical protein implicated in various cellular processes, including synaptic signaling, cell adhesion, and cytoskeletal organization. As a multi-domain protein, CASK interacts with numerous binding partners, influencing neuronal function and development. Dysregulation of CASK has been linked to several neurological disorders and developmental conditions, highlighting its importance in maintaining cellular homeostasis. In recent years, research has focused on understanding the structural and functional dynamics of CASK, particularly in relation to its role in synaptic plasticity and neurotransmitter release. The study of CASK has advanced with the advent of recombinant protein technologies, allowing for the production of high-purity CASK proteins for biochemical and structural studies. These investigations aim to elucidate the precise molecular mechanisms by which CASK exerts its functions, providing insights into potential therapeutic targets for conditions associated with CASK dysfunction. Additionally, the development of CASK-based biosensors and other biotechnological applications underscores its versatility and significance in both fundamental research and clinical settings. As the complexity of CASK interactions with other cellular components is unveiled, it offers a promising avenue for advancing our understanding of cellular signaling pathways and their implications in health and disease.
