Analytical Data
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Gene name
Cathelicidin-4
- Application
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Alternative Names
Indolicidin
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Species
Bovine
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P33046
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Expression Region
131-143aa
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Molecular Weight
17.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Cathelicidin-4 (CATH-4) is a member of the cathelicidin family of antimicrobial peptides, which play a crucial role in the innate immune response of various organisms. Initially discovered in specific vertebrates, such as humans and mice, CATH-4 is known for its potent antimicrobial properties against a wide range of pathogens, including bacteria, viruses, and fungi. Its mechanism of action involves disrupting microbial membranes, leading to cell lysis. Research into CATH-4 is particularly relevant due to the increasing prevalence of antibiotic-resistant infections, making the development of new antimicrobial agents imperative. Furthermore, CATH-4 exhibits additional functions, including immunomodulatory effects, promoting wound healing and modulating inflammatory responses. Studies have shown that this peptide can enhance the activity of other immune cells, thus contributing to a more comprehensive approach to infection control. Additionally, recombinant technology has enabled the production of CATH-4 in vitro, facilitating detailed studies on its structure-function relationship and therapeutic potential. Investigating CATH-4 not only contributes to the fundamental understanding of innate immunity but also opens avenues for the development of novel therapeutics in combating resistant microbial strains and improving clinical outcomes in infectious diseases. As such, CATH-4 represents a promising candidate in the search for effective antimicrobial therapies and serves as a critical focus for further research in immunology and infectious disease management.
