Analytical Data
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Gene name
OBFC1
- Application
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Alternative Names
CST Complex Subunit STN1; Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 1; Suppressor of Cdc Thirteen Homolog; OBFC1; STN1
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
AAH17400.1
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Expression Region
M1-F368
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AA Sequence
MQPGSSRCEEETPSLLWGLDPVFLAFAKLYIRDILDMKESRQVPGVFLYNGHPIKQVDVLGTVIGVRERDAFYSYGVDDSTGVINCICWKKLNTESVSAAPSAARELSLTSQLKKLQETIEQKTKIEIGDTIRVRGSIRTYREEREIHATAYYKVDDPVWNIQIARMLELPTIYRKVYDQPFHSSALEKEEALSNPGALDLPSLTSLLSEKAKEFLMENRVQSFYQQELEMVESLLSLANQPVIHSACSDQVNFKKDTTSKAIHSIFKNAIQLLQEKGLVFQKDDGFDNLYYVTREDKDLHRKIHRIIQQDCQKPNHMEKGCHFLHILACARLSIRPGLSEAVLQQVLELLEDQSDIVSTMEHYYTAF
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Protein Length
Full Length
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Molecular Weight
44 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OBFC1, or Obligate Co-Factor 1, is a crucial protein involved in the maintenance of genomic stability and the regulation of telomere length. Its role has gained significant attention in recent years, particularly in the context of human health and disease. Research indicates that OBFC1 is essential for the proper functioning of telomerase, an enzyme responsible for adding repetitive nucleotide sequences to the ends of chromosomes, thus preventing telomere shortening during cell division. Mutations or dysregulation of OBFC1 have been linked to various disorders, including dyskeratosis congenita and certain forms of cancer, emphasizing its importance in cellular aging and tumorigenesis. Additionally, OBFC1 is involved in DNA damage repair pathways, further highlighting its vital role in maintaining genomic integrity. As researchers continue to explore the structure and function of OBFC1, there is growing interest in its potential as a therapeutic target for diseases associated with telomere dysfunction. Understanding the molecular mechanisms by which OBFC1 operates could provide insights into innovative strategies for combating age-related diseases and improving cancer therapies, making it a significant focus of current biomedical research.
