Analytical Data
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基因名
OBFC1
- Application
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别名
CST Complex Subunit STN1; Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 1; Suppressor of Cdc Thirteen Homolog; OBFC1; STN1
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
AAH17400.1
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表达区间
M1-F368
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氨基酸序列
MQPGSSRCEEETPSLLWGLDPVFLAFAKLYIRDILDMKESRQVPGVFLYNGHPIKQVDVLGTVIGVRERDAFYSYGVDDSTGVINCICWKKLNTESVSAAPSAARELSLTSQLKKLQETIEQKTKIEIGDTIRVRGSIRTYREEREIHATAYYKVDDPVWNIQIARMLELPTIYRKVYDQPFHSSALEKEEALSNPGALDLPSLTSLLSEKAKEFLMENRVQSFYQQELEMVESLLSLANQPVIHSACSDQVNFKKDTTSKAIHSIFKNAIQLLQEKGLVFQKDDGFDNLYYVTREDKDLHRKIHRIIQQDCQKPNHMEKGCHFLHILACARLSIRPGLSEAVLQQVLELLEDQSDIVSTMEHYYTAF
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蛋白长度
Full Length
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分子量
44 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OBFC1, or Obligate Co-Factor 1, is a crucial protein involved in the maintenance of genomic stability and the regulation of telomere length. Its role has gained significant attention in recent years, particularly in the context of human health and disease. Research indicates that OBFC1 is essential for the proper functioning of telomerase, an enzyme responsible for adding repetitive nucleotide sequences to the ends of chromosomes, thus preventing telomere shortening during cell division. Mutations or dysregulation of OBFC1 have been linked to various disorders, including dyskeratosis congenita and certain forms of cancer, emphasizing its importance in cellular aging and tumorigenesis. Additionally, OBFC1 is involved in DNA damage repair pathways, further highlighting its vital role in maintaining genomic integrity. As researchers continue to explore the structure and function of OBFC1, there is growing interest in its potential as a therapeutic target for diseases associated with telomere dysfunction. Understanding the molecular mechanisms by which OBFC1 operates could provide insights into innovative strategies for combating age-related diseases and improving cancer therapies, making it a significant focus of current biomedical research.
