Analytical Data
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Gene name
GBP1
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简介
GBP1 Protein belongs to the dynamin superfamily of large GTPases. GBP1 plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. It hydrolyzes GTP to GMP in two consecutive cleavage reactions. GBP1 also acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. In addition, it exhibits antiviral activity against influenza virus. GBP1 Protein, Human (HEK293, His) is the recombinant human-derived GBP1 protein, expressed by HEK293 , with C-10*His labeled tag.
- Application
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Alternative Names
Guanylate-binding protein 1; GBP-1; HuGBP-1
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Species
Human
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Source
HEK293
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Tag
C-10*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
AAA35871.1
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Expression Region
M1-C589
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Protein Length
Partial
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Molecular Weight
65 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GBP1 (Guanylate Binding Protein 1) is an important member of the guanylate-binding protein family, which plays a crucial role in the immune response and the host's defense against bacterial and viral infections. Research has highlighted GBP1's involvement in various cellular processes, including the regulation of inflammatory responses and the modulation of autophagy. Upon activation by interferons, GBP1 can localize to stress granules and microbial vacuoles, where it participates in pathogen elimination and the regulation of immune signaling pathways. Additionally, GBP1 has been implicated in several diseases, including cancer, where its expression levels can influence tumor progression and metastasis. Understanding the structure and function of GBP1 through protein reconstitution studies can provide insights into its mechanism of action and its potential as a therapeutic target. Recent advancements in molecular biology techniques have facilitated detailed analyses of GBP1's interactions with other proteins and its role in cellular signaling networks. This research is not only vital for comprehending GBP1's biological functions but also has significant implications for developing innovative strategies to enhance immune responses in infectious diseases and cancer therapy. The exploration of GBP1 as a biomarker or a target for drug design could pave the way for novel therapeutic interventions aimed at modulating the immune system effectively.
