Analytical Data
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Gene name
RIPK1
- Application
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Alternative Names
Cell death protein RIP Receptor-interacting protein 1
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Species
Mouse
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Source
Yeast
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Tag
N- His-sumostar
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q60855
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Expression Region
1-656aa
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Molecular Weight
88 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Receptor-interacting protein kinase 1 (RIPK1) plays a crucial role in regulating cell death, inflammation, and survival pathways, making it a significant target for therapeutic intervention in various diseases, including cancer and neurodegenerative disorders. Initially identified as a mediator of tumor necrosis factor (TNF)-induced apoptosis and necroptosis, RIPK1 has garnered attention for its dual role in promoting cell death and facilitating cell survival depending on its interactions with other proteins and the cellular context. The understanding of RIPK1’s function has evolved, revealing its importance in signaling pathways such as NF-κB activation, which is essential for inflammatory responses. Moreover, aberrant RIPK1 activity has been implicated in pathologies where dysregulated apoptosis and inflammation contribute to disease progression. As a result, researchers have focused on producing recombinant RIPK1 proteins to study its structure, interactions, and functional regulation in detail. The development of these recombinant proteins has enabled advanced assays to elucidate the molecular mechanisms underlying RIPK1-mediated signaling and its implications in health and disease. By generating and characterizing RIPK1 recombinant proteins, scientists aim to identify potential modulators that could lead to novel therapeutic strategies targeting RIPK1 pathways, thereby offering insights into the prevention and treatment of diseases associated with dysregulated cell death and inflammation.
