Analytical Data
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Gene name
Tubulin cofactor A
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简介
The tubulin cofactor A protein is a key tubulin folding protein that initiates the tubulin folding pathway within the supercomplex (cofactors A to E). Cofactors A and D capture tubulin and stabilize it in a quasi-native state. Tubulin cofactor A Protein, Human is the recombinant human-derived Tubulin cofactor A protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
Tubulin-specific chaperone A; CFA; TBCA
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75347
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Expression Region
M1-A108
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Protein Length
Full Length
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Molecular Weight
16 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Tubulin cofactor A (TBCoA) plays a crucial role in the assembly of microtubules, which are vital components of the cytoskeleton involved in various cellular processes, including cell division, intracellular transport, and maintaining cell shape. Microtubules are polymeric structures composed of α- and β-tubulin dimers, and their proper formation is essential for normal cellular function. TBCoA assists in the incorporation of tubulin dimers into the growing microtubule structure, regulating their stability and dynamics. Research on recombinant TBCoA has gained importance due to its potential implications in understanding diseases linked to microtubule dysfunction, such as cancer and neurodegenerative disorders. By studying the recombinant form of TBCoA, researchers aim to elucidate its structural and functional properties, which may provide insights into the molecular mechanisms governing microtubule assembly and disassembly. Additionally, understanding TBCoA interactions with other cofactors and tubulin can lead to the development of novel therapeutics that target the microtubule system in pathological conditions. Ultimately, the study of recombinant tubulin cofactor A not only enhances our comprehension of fundamental cellular processes but also opens avenues for biomedical applications in treating diseases where microtubule dynamics are disrupted.
