Analytical Data
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基因名
AANAT
- Application
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别名
AA-NAT; SNAT; Aralkylamine N-Acetyltransferase; Serotonin Acetyltransferase; Serotonin Acetylase; Serotonin N-Acetyltransferase; Melatonin Rhythm Enzyme
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q16613
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表达区间
Met1~Cys207
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分子量
25kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AANAT, or arylalkylamine N-acetyltransferase, is a crucial enzyme involved in the synthesis of melatonin, a hormone that regulates circadian rhythms and sleep-wake cycles. Research on AANAT has gained prominence due to its significant role in various physiological processes, including mood regulation, reproductive functions, and immune response. Understanding AANAT's structure and function can provide insights into how melatonin influences these biological systems and may contribute to developing treatments for sleep disorders, depression, and other related conditions. The purification and characterization of recombinant AANAT protein have been essential for studying the enzyme’s kinetics, substrate specificity, and regulatory mechanisms. Advances in recombinant DNA technology have enabled the expression of AANAT in various systems, facilitating the production of sufficient quantities for in-depth biochemical analyses. This research not only enhances our knowledge of melatonin biosynthesis but also opens new avenues for pharmacological interventions targeting circadian rhythm-related disorders. Overall, AANAT stands as a key player in the realm of chronobiology, and its study is vital for both basic research and clinical applications.
