Analytical Data
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Gene name
TXNDC5
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简介
TXNDC5 Protein, an endoplasmic reticulum lumen-based disulfide isomerase, crucially aids in forming disulfide bonds for protein stability and function. Its ability to reduce disulfide bonds in insulin highlights its role in intricate protein folding processes. TXNDC5's functional attributes make it a key player in preserving the structural integrity of endoplasmic reticulum proteins, contributing to cellular homeostasis. TXNDC5 Protein, Human (GST) is the recombinant human-derived TXNDC5 protein, expressed by E. coli , with N-GST labeled tag.
- Application
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Alternative Names
EndoPDI; Endoplasmic reticulum protein ERp46; Endoplasmic reticulum resident protein 46; Endothelial protein disulphide isomerase; ER protein 46; ERp46; Hcc 2; MGC3178; PDIA15; TLP46; TXND5_HUMAN; TXNDC 5; Txndc5
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Species
Human
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Source
E. coli
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Tag
N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NBS9-2
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Expression Region
R33-L324
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AA Sequence
MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQAKDEL
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Protein Length
Partial
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Molecular Weight
63.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TXNDC5, a member of the thioredoxin (Trx) family, has attracted significant attention in recent years due to its potential roles in various cellular processes and diseases. This protein is known for its involvement in the oxidative stress response, where it participates in the reduction of disulfide bonds and maintains cellular redox homeostasis. The expression of TXNDC5 is often upregulated in certain cancer types, suggesting it may play a crucial role in tumorigenesis and cancer progression. Additionally, TXNDC5 has been implicated in the regulation of cell signaling pathways, protein folding, and the endoplasmic reticulum (ER) stress response. Given its significant biological functions, researchers are increasingly interested in producing and characterizing recombinant TXNDC5 to better understand its molecular mechanisms and potential therapeutic applications. By studying the recombinant form of TXNDC5, scientists aim to elucidate its structure-function relationship, explore its interactions with other proteins, and assess its potential as a target for drug development, particularly in cancer therapy. The research surrounding TXNDC5 could provide valuable insights into its role in human diseases and pave the way for novel therapeutic strategies.
