Analytical Data
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Gene name
Neuroligin-3/NLGN3
- Application
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Alternative Names
ASPGX1; AUTSX1; HNL3; NL3; Gliotactin homolog
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9NZ94
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Expression Region
Pro40~Ile289
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Molecular Weight
31kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Neuroligin-3 (NLGN3) is a crucial synaptic adhesion molecule that plays a significant role in the development and maintenance of synapses in the central nervous system. Mutations in the NLGN3 gene have been linked to neurodevelopmental disorders, particularly autism spectrum disorders (ASD), highlighting its importance in neuronal communication and plasticity. NLGN3 interacts with neurexins on presynaptic neurons, facilitating synapse formation and influencing excitatory and inhibitory synaptic transmission. The study of recombinant NLGN3 proteins has gained attention as a means to elucidate its functional mechanisms, enabling researchers to investigate how specific mutations affect its structure and function. By producing recombinant NLGN3, scientists can explore its binding characteristics, signaling pathways, and the impact of genetic variations on synaptic function. This research not only aids in understanding the molecular underpinnings of ASD but also provides insights into potential therapeutic strategies targeting synaptic dysfunctions in various neurodevelopmental disorders. Given the critical role of NLGN3 in synaptic health, the exploration of its recombinant proteins represents a promising avenue for identifying biomarkers and novel interventions for conditions associated with synaptic dysregulation.
