Analytical Data
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基因名
TAOK3
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简介
TAOK3, a kinase, regulates the p38/MAPK14 and MAPK8/JNK cascades. It activates the p38/MAPK14 cascade, particularly in DNA damage-induced G2/M transition, likely through MAP2K3 and MAP2K6 phosphorylation. TAOK3 inhibits basal MAPK8/JNK activity and dampens its response to epidermal growth factor. These functions showcase TAOK3's role in coordinating cellular responses to DNA damage and growth factor signaling. TAOK3 Protein, Human (sf9, His, GST) is the recombinant human-derived TAOK3 protein, expressed by Sf9 insect cells, with N-His and N-GST labeled tag.
- Application
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别名
Serine/threonine-protein kinase TAO3; JNK/SAPK-inhibitory kinase; DPK; JIK; KDS; MAP3K18
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种属
Human
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表达系统
Baculovirus
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标签
N-His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H2K8-1
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表达区间
M1-D411
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蛋白长度
Partial
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分子量
85 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TAOK3 (TAO Kinase 3) is a serine/threonine kinase that belongs to the TAO family of proteins, which are known to play significant roles in various cellular processes, including apoptosis, neurogenesis, and the regulation of the cytoskeleton. Recent research has highlighted its involvement in neurodevelopmental disorders and certain forms of cancer, making it a target of interest in both basic and translational biology. Mutations and dysregulation of TAOK3 have been implicated in conditions such as autism spectrum disorders and other neuropsychiatric conditions, suggesting a crucial role in central nervous system development and function. The understanding of TAOK3's function has been limited due to the lack of detailed studies on its structural biology and biochemical properties. The recombinant expression of TAOK3 in various systems offers the potential to elucidate its molecular mechanisms, interactions with upstream and downstream signaling pathways, and its role in disease pathology. By studying the recombinant TAOK3 protein, researchers aim to provide insights into its enzymatic activity, substrate specificity, and potential as a therapeutic target. Overall, the investigation of TAOK3 and its recombinant protein serves as a promising avenue for advancing our understanding of complex biological processes and developing novel therapeutic strategies for related disorders.
