Analytical Data
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基因名
VEGFR-2
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简介
VEGFR-2 Protein is a type III receptor tyrosine kinase, also known as the receptor for vascular endothelial growth factor 2. VEGFR-2 Protein mediates vascular endothelial growth factor (VEGF)-induced endothelial proliferation, survival, migration, tubular morphogenesis, and sprouting, and plays a key role in angiogenesis and vasculogenesis. VEGFR-2 Protein, Rat (HEK293, His) is the recombinant rat-derived VEGFR-2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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生物活性
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human VEGF 165 is present at 2 μg/mL can bind Rat VEGFR-2. The ED50 for this effect is 98.18 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human VEGF 165 is present at 2 μg/mL can bind Rat VEGFR-2. The ED50 for this effect is 98.18 ng/mL.
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别名
Vascular endothelial growth factor receptor 2; VEGFR-2; FLK-1; CD309
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种属
Rat
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 95% as determined by reducing SDS-PAGE.
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蛋白编号
AAH87029
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表达区间
A20-E760
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氨基酸序列
ASVGLPGDSLHPPKLSTQKDILTILANTTLQITCRGQRDLDWLWPNTPRDSEERVLVTECGDSIFCKTLTVPRVVGNDTGAYKCFYRDTDVSSIVYVYVQDHRSPFIASVSDEHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRFVPDGNRISWDSEKGFTIPSYMISYAGMVFCEAKINDETYQSIMYIVLVVGYRIYDVVLSPPHEIELSAGEKLVLNCTARTELNVGLDFSWQFPSSKHQHKKIVNRDVKSLPGTVAKMFLSTLTIDSVTKSDQGEYTCTAYSGLMTKKNKTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIPVKYLSYPAPDIKWYRNGRPIESNYTMIVGDELTIMEVSERDAGNYTVILTNPISMEKQSHMVSLVVNVPPQIGEKALISPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYRPSQTNPYTCKEWRHVKDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYKCEAINKAGRGERVISFHVIRGPEITVQPATQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPVCKNLDALWKLNGTVFSNSTNDILIVAFQNASLQDQGNYVCSAQDKKTKKRHCLVKQLVILERMAPMITGNLENQTTTIGETIEVVCPTSGNPTPLITWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLE
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蛋白长度
Partial
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分子量
115-180 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Vascular endothelial growth factor receptor 2 (VEGFR-2) is a key receptor involved in the process of angiogenesis, which is the formation of new blood vessels from pre-existing ones. This protein is predominantly expressed in endothelial cells and plays a critical role in regulating vascular permeability, blood vessel formation, and the response to hypoxia. Dysregulation of VEGFR-2 signaling is associated with various diseases, including cancer, where tumor growth and metastasis often depend on the formation of new blood vessels to supply nutrients and oxygen. The study of VEGFR-2 recombinant proteins has gained significant attention as they offer potential therapeutic avenues for anti-angiogenic strategies. Researchers are particularly interested in understanding the structural and functional properties of VEGFR-2, which can lead to the development of novel inhibitors that can block its activity. Such efforts may provide a means to inhibit tumor growth and reduce the spread of cancer, making VEGFR-2 a valuable target in the design of cancer therapies. The development of VEGFR-2 recombinant proteins also facilitates the exploration of its role in vascular biology and other physiological processes, ultimately contributing to the advancement of therapeutic options for related diseases.
