Analytical Data
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Gene name
NKp46/NCR1
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简介
NKp46/NCR1 Protein is a major NK cell-activating receptor that is involved in the elimination of target cells and recognizing a wide range of tumors, viruses, and bacteria. NKp46 forms microclusters structures at the immune synapse between NK cells and target cells. Over-expression of human NKp46 is correlated with increased accumulation of F-actin mesh at the immune synapse. NKp46 signaling directly regulates the NK lytic immune synapse from early formation to late function[1][2][3]. NKp46/NCR1 Protein, Human (Biotinylated, HEK293, His, solution) is the recombinant human-derived NKp46/NCR1 protein, expressed by HEK293, with N-His labeled tag.
- Application
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Alternative Names
CD335; Ly94; NCR1; NKp46; MAR-1; NKP46FLJ99094
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Species
Human
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Source
HEK293
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Tag
N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
AAH64806
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Expression Region
Q22-D254
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Protein Length
Partial
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Molecular Weight
38-48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NKp46, also known as NCR1, is a receptor expressed on natural killer (NK) cells, which play a crucial role in the innate immune response against tumors and viral infections. The significance of NKp46 lies in its ability to recognize and bind to specific ligands on target cells, facilitating the activation of NK cells and promoting cytotoxicity. Research on NKp46 has intensified due to its potential as a therapeutic target in cancer immunotherapy and infectious diseases. The recombinant protein form of NKp46, generated through molecular cloning and expression systems, enables detailed studies of its structure-function relationship, ligand specificity, and signaling pathways. Furthermore, this recombinant NKp46 can be used in various experimental applications, including the development of antibodies, assays for NK cell activation, and elucidating mechanisms of immune regulation. Understanding NKp46's role and interactions not only deepens our knowledge of NK cell biology but also informs strategies for enhancing anti-tumor immunity and developing novel immunotherapeutic agents, thus addressing critical challenges in oncology and infectious disease management.
