Analytical Data
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Gene name
M1R
- Application
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Species
Virus
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
QJQ40223
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Expression Region
G2-G183
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Protein Length
Partial
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Molecular Weight
23-38 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
M1R, or Muscarinic Acetylcholine Receptor M1, is a G protein-coupled receptor (GPCR) that plays a significant role in various physiological processes, including cognitive function and neurotransmission in the central nervous system. Research on M1R has gained momentum due to its involvement in neurodegenerative diseases such as Alzheimer’s disease and schizophrenia, where its dysregulation has been linked to cognitive deficits. The receptor is primarily activated by acetylcholine, leading to a cascade of intracellular signaling pathways that influence neuronal excitability and synaptic plasticity. Given its crucial function in modulating synaptic transmission and plasticity, M1R is considered a potential therapeutic target for cognitive enhancement and neuroprotection. The development of M1R recombinant proteins has facilitated in-depth studies of its structure, function, and interactions with various ligands. By utilizing techniques such as site-directed mutagenesis and crystallography, researchers aim to elucidate the molecular mechanisms underlying M1R activation and signaling, which could pave the way for the design of novel drugs that selectively modulate M1R activity. Understanding the intricate dynamics of M1R not only provides insights into the basic principles of GPCR biology but also holds promise for addressing cognitive impairments associated with various psychiatric and neurodegenerative disorders.
