Analytical Data
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Gene name
PRMT6
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简介
PRMT6 is a multifunctional arginine methyltransferase that prefers the formation of asymmetric dimethylarginine (aDMA) and methylates arginine residues within glycine- and arginine-rich domains change. It coordinates asymmetric dimethylation of histone H3 "Arg-2" to generate H3R2me2a, a unique epigenetic tag associated with transcriptional repression. PRMT6 Protein, Human (HEK293, His-Flag) is the recombinant human-derived PRMT6 protein, expressed by HEK293 , with N-Flag, C-His labeled tag.
- Application
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Alternative Names
Protein arginine N-methyltransferase 6; PRMT6; HRMT1L6
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Species
Human
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Source
HEK293
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Tag
N-Flag;C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96LA8-1
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Expression Region
M1-D375
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Protein Length
Full Length of Isoform-1
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Molecular Weight
43-46
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRMT6 (Protein Arginine Methyltransferase 6) is an important member of the arginine methyltransferase family, which plays a crucial role in the post-translational modification of proteins through the methylation of arginine residues. This modification is essential for various biological processes, including gene expression regulation, RNA processing, and signal transduction. Dysregulation of PRMT6 has been implicated in several diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Research on recombinant PRMT6 has gained momentum as scientists seek to understand its structure-function relationships and the molecular mechanisms underlying its activity. Recombinant protein expression allows for the production of large quantities of PRMT6 for biochemical assays, structural studies, and drug development. Additionally, understanding the enzymatic activity and substrate specificity of PRMT6 can provide insights into its biological roles and interactions with other proteins. Overall, the study of recombinant PRMT6 is pivotal for elucidating its functions in health and disease, paving the way for potential therapeutic interventions.
