Analytical Data
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Gene name
CPVL
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简介
CPVL protein, a serine carboxypeptidase, may be involved in the digestion of phagocytic granules in lysosomes and in the inflammatory protease cascade. CPVL protein, a potential biomarker, may promote glioma progression by inhibiting STAT1 phosphorylation. CPVL Protein, Human (HEK293, His) is the recombinant human-derived CPVL protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
rHuProbable serine carboxypeptidase CPVL, His; Probable serine carboxypeptidase CPVL; Carboxypeptidase vitellogenic-like; Vitellogenic carboxypeptidase-like protein; VCP-like protein; CPVL
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
AAH16838.1
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Expression Region
L23-G476
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AA Sequence
LFRSLYRSVSMPPKGDSGQPLFLTPYIEAGKIQKGRELSLVGPFPGLNMKSYAGFLTVNKTYNSNLFFWFFPAQIQPEDAPVVLWLQGGPGGSSMFGLFVEHGPYVVTSNMTLRDRDFPWTTTLSMLYIDNPVGTGFSFTDDTHGYAVNEDDVARDLYSALIQFFQIFPEYKNNDFYVTGESYAGKYVPAIAHLIHSLNPVREVKINLNGIAIGDGYSDPESIIGGYAEFLYQIGLLDEKQKKYFQKQCHECIEHIRKQNWFEAFEILDKLLDGDLTSDPSYFQNVTGCSNYYNFLRCTEPEDQLYYVKFLSLPEVRQAIHVGNQTFNDGTIVEKYLREDTVQSVKPWLTEIMNNYKVLIYNGQLDIIVAAALTERSLMGMDWKGSQEYKKAEKKVWKIFKSDSEVAGYIRQAGDFHQVIIRGGGHILPYDQPLRAFDMINRFIYGKGWDPYVG
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Protein Length
Partial
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Molecular Weight
54-65 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CPVL (Cardiac Progestin Receptor-Associated Protein) is a member of the family of proteins involved in various cellular processes, especially in cardiac and nervous system functions. Recent research has highlighted the pivotal role of CPVL in mediating cellular responses to progestins, which are steroid hormones influencing reproductive and cardiovascular health. The understanding of CPVL's structure and function is crucial, as its dysregulation has been implicated in several pathological conditions, including heart diseases and certain cancers. The recombinant expression of CPVL provides an opportunity to study its biochemical properties, cellular interactions, and therapeutic potentials. By employing advanced molecular cloning and protein purification techniques, researchers aim to produce large quantities of functional CPVL for detailed investigations, allowing for insights into its mechanism of action and potential as a drug target. The growing interest in the role of CPVL in disease mechanisms emphasizes the need for comprehensive studies that could lead to innovative strategies for diagnostics and treatment in cardiac and hormonal disorders.
