Analytical Data
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基因名
OX40 Ligand/TNFSF4
- Application
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种属
Cynomolgus; Rhesus Macaque
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表达系统
HEK293
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标签
N-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A0A2K5TTN0
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表达区间
Q81-L213
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蛋白长度
Partial
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分子量
25-38 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OX40 Ligand, also known as TNFSF4, is a pivotal member of the tumor necrosis factor (TNF) superfamily that plays a crucial role in regulating immune responses, particularly in T-cell activation and survival. It is expressed primarily on antigen-presenting cells and binds to the OX40 receptor on T cells, facilitating their proliferation, differentiation, and long-term persistence. The OX40/OX40L interaction has emerged as a significant target in immunotherapy, particularly in enhancing anti-tumor immune responses. Understanding the structural and functional dynamics of the OX40 ligand, and developing recombinant forms of this protein, has garnered substantial interest in both basic and clinical research. Recombinant OX40L proteins are being utilized to explore their potential in cancer treatments and autoimmune diseases by modulating T-cell activity. Additionally, the functional characterization of OX40L could provide insights into its role in various pathological conditions, paving the way for novel therapeutic strategies. As such, the study of OX40 Ligand/TNFSF4 not only expands the knowledge of immune modulation but also holds promise for innovative approaches in targeted therapies for cancer and other immune-related disorders.
