Analytical Data
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基因名
Integrin alpha 2 beta 1 Heterodimer
- Application
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种属
Cynomolgus
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
G8F2Z5 (Y30-P1130)&A0A7N9D0D7
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表达区间
G8F2Z5 (Y30-P1130)&A0A7N9D0D7 (Q161-D868)
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分子量
130-170 kDa (ITGA2) & 100-130 kDa (ITGB1)
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Integrin alpha 2 beta 1 heterodimer is a crucial receptor that mediates cell adhesion to extracellular matrix components, particularly collagen, playing a vital role in various biological processes such as cell migration, proliferation, and differentiation. The significance of this integrin in physiological and pathological contexts, including wound healing, tissue repair, and tumor metastasis, has spurred research into its structure and function. Understanding the integrin alpha 2 beta 1 complex is essential for developing targeted therapies for diseases where cell-cell and cell-matrix interactions are disrupted. The ability to produce recombinant forms of this integrin heterodimer has advanced research, allowing for detailed structural studies and functional assays. By using recombinant proteins, scientists can investigate the integrin's role in cellular signaling pathways and its interactions with other proteins, leading to enhanced knowledge of its mechanistic functions in health and disease. Additionally, insights gained from these studies could lead to the development of integrin-targeted drugs or therapies, offering new avenues for treating disorders related to abnormal integrin activity.
