Analytical Data
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Gene name
Integrin alpha 2 beta 1 Heterodimer
- Application
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Species
Cynomolgus
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
G8F2Z5 (Y30-P1130)&A0A7N9D0D7
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Expression Region
G8F2Z5 (Y30-P1130)&A0A7N9D0D7 (Q161-D868)
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Molecular Weight
130-170 kDa (ITGA2) & 100-130 kDa (ITGB1)
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Integrin alpha 2 beta 1 heterodimer is a crucial receptor that mediates cell adhesion to extracellular matrix components, particularly collagen, playing a vital role in various biological processes such as cell migration, proliferation, and differentiation. The significance of this integrin in physiological and pathological contexts, including wound healing, tissue repair, and tumor metastasis, has spurred research into its structure and function. Understanding the integrin alpha 2 beta 1 complex is essential for developing targeted therapies for diseases where cell-cell and cell-matrix interactions are disrupted. The ability to produce recombinant forms of this integrin heterodimer has advanced research, allowing for detailed structural studies and functional assays. By using recombinant proteins, scientists can investigate the integrin's role in cellular signaling pathways and its interactions with other proteins, leading to enhanced knowledge of its mechanistic functions in health and disease. Additionally, insights gained from these studies could lead to the development of integrin-targeted drugs or therapies, offering new avenues for treating disorders related to abnormal integrin activity.
