Analytical Data
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基因名
KAT5
- Application
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别名
HTATIP; ESA1; HTATIP1; PLIP; TIP; TIP60; cPLA2; HIV-1 Tat Interacting Protein,60kDa; 60 kDa Tat-interactive protein; Lysine acetyltransferase 5; Histone acetyltransferase HTATIP
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q92993
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表达区间
Tyr294~Trp513
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分子量
30kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KAT5, also known as Lysine Acetyltransferase 5, is an essential enzyme involved in various cellular processes, including gene regulation, DNA repair, and cell cycle progression. Its primary function is to acetylate lysine residues on histones and non-histone proteins, thereby modulating chromatin structure and influencing gene expression. Dysregulation of KAT5 has been implicated in several diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. The interest in KAT5 research has surged in recent years due to its potential as a therapeutic target. Knowing its role in both pathological and physiological contexts, researchers have focused on unraveling its specific mechanisms of action, substrate specificity, and regulatory pathways. Investigating KAT5 and its interactions with other key molecular players could lead to the development of innovative strategies for disease intervention, including the design of selective inhibitors that could restore normal acetylation patterns in disease states. This makes KAT5 a prominent focus in the fields of epigenetics and drug discovery, as understanding its function could pave the way for novel treatments aimed at correcting acetylation imbalances associated with various health conditions.
