Analytical Data
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Gene name
ESD
- Application
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Alternative Names
S-formylglutathione hydrolase; FGH; Esterase D; Methylumbelliferyl-acetate deacetylase (EC:3.1.1.56)
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
3FCX_A
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Expression Region
M1-A282
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Protein Length
Full Length
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Molecular Weight
34 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ESD (Enhanced Sensitivity to DNA Damage) recombinant proteins have garnered significant attention in the fields of molecular biology and genetics due to their crucial role in cellular responses to DNA damage and repair mechanisms. Originally discovered in studies related to cancer biology, ESD proteins are implicated in regulating cell survival and apoptosis in response to genotoxic stress. Their ability to enhance sensitivity to DNA-damaging agents underscores their potential as biomarkers for cancer susceptibility and prognosis. Recent research has focused on the structural and functional characterization of ESD recombinant proteins, aiming to elucidate their mechanisms of action at the molecular level. Advances in protein engineering techniques have facilitated the production of these recombinant proteins in various expression systems, allowing scientists to investigate their interactions with key cellular components, such as repair enzymes and signaling pathways. Moreover, the study of ESD proteins offers promising avenues for therapeutic interventions, particularly in enhancing the efficacy of radiotherapy and chemotherapy by targeting the DNA damage response in tumor cells. As our understanding of ESD proteins deepens, their potential applications in personalized medicine and cancer treatment strategies continue to expand, highlighting the importance of ongoing research in this dynamic area of study.
