Analytical Data
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基因名
Musk
- Application
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别名
Muscle-specific tyrosine-protein kinase receptor
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15146
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表达区间
24-495aa
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分子量
56.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Musk (Muscle-Specific Kinase) is a crucial molecule in the development and function of neuromuscular junctions, where motor neurons communicate with skeletal muscle fibers. This protein is a receptor tyrosine kinase that plays a key role in synapse formation and maintenance by interacting with molecules such as acetylcholine receptors. Mutations in the MUSK gene have been implicated in congenital myasthenic syndromes, resulting in neuromuscular transmission defects. Consequently, understanding the structural and functional aspects of Musk is essential for elucidating its role in muscle physiology and pathophysiology. Recent studies have focused on elucidating the protein's three-dimensional structure and its interactions with various ligands and intracellular partners, which can provide insights into its signaling pathways and regulatory mechanisms. Furthermore, research into Musk has potential therapeutic implications, including the development of targeted treatments for neuromuscular disorders. By investigating Musk's molecular dynamics and its functional domains, researchers aim to unravel the complexities of neuromuscular junction biology and explore avenues for innovative interventions in diseases associated with its dysfunction.
