Analytical Data
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基因名
IRS1
- Application
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别名
HIRS1
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P35569
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表达区间
Pro837~Gln1089
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分子量
30kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IRS1 (Insulin Receptor Substrate 1) is a pivotal adaptor protein that plays a crucial role in insulin signaling pathways and metabolic regulation. Alterations in IRS1 function or expression have been implicated in various metabolic disorders, including obesity, insulin resistance, and type 2 diabetes. The study of IRS1 recombinant protein offers significant insights into its structural and functional properties, enabling researchers to explore its interactions with insulin receptors and downstream signaling molecules such as PI3K and Akt. Recombinant IRS1 serves as a valuable tool for elucidating the mechanisms by which insulin signaling is impaired in metabolic diseases. Furthermore, understanding the phosphorylation dynamics and the impact of post-translational modifications on IRS1 activity can aid in identifying potential therapeutic targets for enhancing insulin sensitivity. Recent advances in molecular biology techniques have facilitated the production and characterization of IRS1 as a recombinant protein, allowing for detailed functional assays and structural analyses. This research is essential for developing novel strategies to combat the rising prevalence of metabolic disorders and improving our understanding of insulin signaling pathways.
