Analytical Data
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基因名
SPT16
- Application
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别名
FACT complex subunit SPT16; Facilitates chromatin transcription complex subunit SPT16; SPT16; Arabidopsis thaliana; Mouse-ear cress
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种属
Others
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O82491
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表达区间
L662-L952
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The SPT16 protein, part of the FACT (Facilitates Chromatin Transcription) complex, plays a crucial role in chromatin dynamics and transcription regulation. It facilitates the restructuring of nucleosomes, allowing for the effective progression of RNA polymerase II during transcription. Research into SPT16 has gained traction due to its implications in both cellular processes and disease states, particularly cancer, where dysregulation of transcription machinery can lead to aberrant gene expression. Understanding SPT16's structure and function, as well as its interactions with other components of the FACT complex, is vital for elucidating the mechanisms that govern chromatin accessibility and gene expression. Furthermore, investigations have shown that SPT16 is involved in DNA repair processes, highlighting its importance beyond transcription. Given the multifaceted role of SPT16, studies focusing on its biochemical properties, regulatory mechanisms, and interactions with other transcription factors and chromatin remodelers are critical for developing potential therapeutic targets. The evolving knowledge surrounding SPT16 underscores its potential as a key player in epigenetic regulation and a promising focus for future research aimed at addressing transcription-related pathologies.
