Analytical Data
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Gene name
IL-22R alpha 1
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简介
IL-22R α 1 and IL-10R β together form IL20, IL22 and IL24 receptor complexes, activating different signaling pathways. Within the IL22 receptor, IL-22R α 1 binds to IL10RB and mediates IL22 signaling through the JAK/STAT and MAPK1/MAPK3/Akt pathways. IL-22R alpha 1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-22R alpha 1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
IL-22R-alpha-1; IL-22RA1; CRF2-9; IL22R; IL22R1; IL-TIF-R1; zcytoR11
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Species
Cynomolgus
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Source
HEK293
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Tag
C-8*His
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Purity
> 90% as determined by SDS-PAGE.
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Uniprot
A0A2K5TKX9
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Expression Region
P18-T225
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Protein Length
Extracellular Domain
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Molecular Weight
38-48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-22R alpha 1, a critical receptor component for interleukin-22 (IL-22), plays a significant role in mediating immune responses and tissue homeostasis. IL-22, produced primarily by T-helper 17 (Th17) cells, is known for its protective functions in epithelial tissues, where it promotes cell proliferation, enhances barrier function, and supports tissue repair. The interaction between IL-22 and its receptor, IL-22R alpha 1, is crucial in various physiological and pathological contexts, including infections, autoimmune diseases, and chronic inflammatory conditions. Research on IL-22R alpha 1 recombinant protein aims to better understand its structural properties and signaling mechanisms, which could provide insights into developing therapeutic strategies targeting IL-22 signaling pathways. By generating and characterizing IL-22R alpha 1 recombinant protein, scientists can explore its potential as a biomarker or therapeutic target in diseases linked to dysregulated IL-22 signaling. Furthermore, studying this receptor's role in orchestrating immune responses highlights its potential impact on therapeutic approaches for inflammatory diseases, making IL-22R alpha 1 a promising focus for further research and drug development.
