Analytical Data
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基因名
HLA-A
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简介
HLA-A protein is an antigen-presenting MHCI molecule that is critical for mediating reproductive and antiviral immunity. It partners with B2M to provide self- and viral peptides as ligands that inhibit and activate KIR on NK cells. HLA-A Protein, Human (His) is the recombinant human-derived HLA-A protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
HLA class I histocompatibility antigen,A-1 alpha chain
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P04439-1
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表达区间
G25-I308
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氨基酸序列
GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPI
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蛋白长度
Extracellular Domain
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分子量
36.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of HLA-A recombinant proteins is rooted in the pivotal role that Human Leukocyte Antigen (HLA) molecules play in the immune response and organ transplantation. HLA-A is a critical class I molecule, responsible for presenting endogenous peptides to CD8+ T cells, thus facilitating the detection of infected or malignant cells by the immune system. Understanding the structural and functional characteristics of HLA-A is essential for improving transplant compatibility and developing effective immunotherapies. Researchers have focused on producing recombinant HLA-A proteins to study their antigen-binding properties, interactions with T cell receptors, and implications in autoimmune diseases and cancer. These recombinant proteins serve as valuable tools for vaccine development, as they can help identify epitopes that elicit robust immune responses. Additionally, the exploration of HLA-A variants can provide insights into population genetics and disease susceptibility, ultimately aiding in personalized medicine approaches. Advances in protein engineering and expression systems have enabled the production of high-purity HLA-A recombinant proteins, making them readily accessible for various biomedical applications. Thus, the research on HLA-A recombinant proteins is vital for enhancing our understanding of immune mechanisms and improving therapeutic strategies in transplantation and cancer immunotherapy.
