Analytical Data
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基因名
Thymidine kinase 1/TK1
- Application
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别名
TK2; Thymidine kinase, cytosolic
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P04183
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表达区间
Ser2~Asn234
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分子量
55kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Thymidine kinase 1 (TK1) is a crucial enzyme involved in the salvage pathway of nucleotide synthesis, specifically responsible for phosphorylating thymidine to thymidine monophosphate. This enzyme plays a significant role in DNA synthesis and repair, particularly in rapidly dividing cells, which makes it an important biomarker for cellular proliferation. Abnormal levels of TK1 have been associated with various cancers, viral infections, and other diseases, highlighting its potential as a diagnostic and therapeutic target. Recombinant TK1 proteins are extensively used in research to enhance our understanding of its role in tumor biology and to develop novel cancer therapies. Additionally, the production of recombinant TK1 allows for the study of its structural and functional properties, paving the way for the development of TK1 inhibitors. These inhibitors could potentially serve as anti-cancer agents by targeting tumor cell proliferation. Moreover, research involving TK1 can contribute to better diagnostic tools for monitoring therapeutic responses and disease progression in cancer treatment. Understanding the regulation and expression of TK1 in different pathological contexts could lead to significant advancements in targeted therapies and personalized medicine.
