Analytical Data
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Gene name
CD72
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简介
CD72 Protein plays a key role in orchestrating B-cell proliferation and differentiation, forming homodimers with disulfide linkages and interacting with CD5. It engages in tyrosine phosphorylation interactions with PTPN6/SHP-1, indicating its modulation of cellular responses through phosphorylation-based regulatory mechanisms. This underscores the multifaceted role of CD72 in the dynamic landscape of B-cell function and signaling. CD72 Protein, Human (HEK293, His) is the recombinant human-derived CD72 protein, expressed by HEK293 , with labeled tag.
- Application
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Alternative Names
CD72; Lyb-2; Lyb2
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Species
Human
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Source
HEK293
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Tag
N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P21854
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Expression Region
R117-D359
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Protein Length
Extracellular Domain
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Molecular Weight
32-40 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD72 is a type II transmembrane protein predominantly expressed on B cells and plays a significant role in regulating immune responses. As a member of the C-type lectin family, CD72 acts as an adhesive molecule, mediating interactions between B cells and other immune cells, thereby influencing B cell activation, survival, and differentiation. Research has shown that CD72 engagement can modulate various signaling pathways, including those associated with the tonic signaling required for B cell development and the initiation of immune responses. Its interactions with ligands, such as CD100, are critical for the formation of immune synapses, revealing its importance in the coordination of immune functions. The study of CD72 and its recombinant protein has gained attention for their potential applications in immunotherapies and vaccine development, as understanding its precise mechanisms could lead to novel strategies in treating autoimmune diseases, allergies, and other immunological disorders. Additionally, the generation of CD72 recombinant proteins allows for detailed structural and functional analyses, which can provide insights into its role in immune regulation and help identify new therapeutic targets. Overall, ongoing research on CD72 and its recombinant forms holds promise for advancing our understanding of B cell biology and developing innovative solutions for immune-related diseases.
